rezvani lab:berlin

Our lab develops strategies for in vivo tissue regeneration and studies complex organ development in organoids.

The Rezvani lab at Charité University Medicine Berlin–a team of biologists and clinician-scientists–aims to identify new signals that can restore normal liver function and encourage regeneration in cases of chronic injuries.

To achieve this, we create innovative human organoids with a syngeneic immune system to reverse-engineer inter-lineage pathophysiologies since many chronic liver diseases are impacted by inflammation.

Our “toolbox” includes humanized mice, CRISPR screens, multiplexed patient specimen analysis, computational predictions and more. We believe in methodical creativity, transparency, teamwork and focused work to move the field forward.

Our ultimate goal is to develop therapeutic strategies to treat fibro-inflammatory processes in chronic liver diseases. Importantly, we regard many rare pediatric liver diseases as real-life models for common conditions.